Halo-Ed Portal: The
DasSarma Group Virtual Lab |
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Welcome to the Halo-Ed Portal! |
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The DasSarma Laboratory has focused on extreme
halophiles* called Haloarchaea, for over 35 years. Professor
Shiladitya DasSarma first encountered Halobacterium sp. during his
PhD studies at MIT in the laboratory of Prof Har Gobind Khorana, Nobel
Laureate and co-discoverer of the genetic code. [Hear DasSarma's tribute lecture for Prof Khorana on his birth
centenary in January 2022.] The genetic code and genome sequencing, including
the Halobacterium sp. genome sequence, have allowed our research to
become primarily bioinformatic and virtual. Prof. DasSarma's independent career working
with Halobacterium sp. began at the University of Massachusetts at
Amherst, where he served on the faculty in the Department of Microbiology
(1986-2001). The Halobacterium sp. genome sequencing project was led
by the DasSarma group and published
in October 2000. Then he moved his laboratory to the University of Maryland
Biotechnology Institute (2001-2010), and University of Maryland School of
Medicine, Department of Microbiology and Immunology, Institute of Marine and
Environmental Technology (2010–present). For more on Professor DasSarma’s Purple Earth
Hypothesis, featured by ASM’s
Small Things Considered, GVNP technology,
and other discoveries in his research career, check out his interview on the DG Early-Morning Show
and New
York Times. The work in the DasSarma Laboratory has
inspired the evolution of the fields of Haloarchaeal research, including
sequencing the first Haloarchaeal genome, that of Halobacterium sp. NRC-1, Astrobiology, including
positing the Purple
Earth Hypothesis,
that has gained much recognition,
as well as a plethora of biomedical and biotechnological applications,
including bioremediation, vaccine and antigen delivery as well as cancer therapeutics. The laboratory has also
hosted artists and inspired a number of artistic endeavors (see e.g. Pin
Vega and Michele Hagewood).
Priya DasSarma, an accomplished microbiologist and Research
Scientist at BMSIS, is a long-time collaborator. She was educated at the
University of Vienna, Austria and the University of Massachusetts, Amherst,
USA. She has been fascinated by Halophiles and Extreme Microbiology for many
years, and specializes in microbiology and biotechnology research, education
and outreach using Halobacterium sp. and related haloarchaea (see our American
Biology Teacher Cover Feature). To read an early review from the DasSarma
lab, including a bio, click here. *The term Halo comes from the Greek,
meaning sea/salt – and these microbes
are salt-loving (halophilic). |
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Complete list of publications from the DasSarma
lab with access to reprints and the Halophile Laboratory Manual. |
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Halo-Gen is a
bioinformatics resource for exploring Haloarchaeal genomes using readily
available tools. We provide background and information on many Haloarchaeal
strains that have been fully sequenced. |
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HaloWeb is our
classic Haloarchaeal genomes resource, that allows one manipulate
Haloarchaeal genomes, including visualizing genes and gene regions, producing
maps, analyzing data using online tools, and includes our Sequence
Editor. |
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Halo-Ed has
resources for educators and students interested in halophiles and ways to
explore them online and in the laboratory. We provide background information,
videos and modules for learning about and working with Haloarchaea. |
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MolGenT is a
powerful, self-guided Molecular Genetics Tutorial. This includes video, audio
and text and culminates with a test that can be submitted in order to obtain
a Certificate from the Halo-Ed Team. |
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We love sharing
other resources, and have listed some of our favorites, including some tips
for use. Let us know if you would like to
recommend others for us to check out. |
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Interested
students are encouraged to apply for grants, scholarships and fellowships to work
in the DasSarma Laboratory. |
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Did you know? Flamingos
get their spectacular color from the food they eat – including red and pink
from Haloarchaea! |
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For Questions and Suggestions, contact the Halo-Ed Team |
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Copyright © Shiladitya DasSarma & Priya
DasSarma |